Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Patel, Pushpendra Kumar
- Effects of Methanolic Extracts of Quisqualis indica (Aerial Parts) on Passive Smoking Induced Hyperlipidemia in Rats
Abstract Views :341 |
PDF Views:1
Authors
Affiliations
1 T.I.T. College of Pharmacy, Department of Pharmacology, Anand Nagar, Bhopal, Madhya Pradesh, IN
1 T.I.T. College of Pharmacy, Department of Pharmacology, Anand Nagar, Bhopal, Madhya Pradesh, IN
Source
Asian Journal of Pharmacy and Technology, Vol 3, No 1 (2013), Pagination: 26-29Abstract
In the present study the hypolipidemic activity of methanolic extracts of aerial parts of Quisqualis indica (QI) including flowers on passive smoking (PS) induced hyperlipidemia in rats had been evaluated. Hyperlipidemia was induced by passive smoking in a closed chamber having 1 burning ciggrette inside it. The hypolipidemic activity was analysed by reading the blood serum level in UV at 505 nm after treated with reagent present in auto span diagnostic kit. Dose of Methanolic extracts of QI had been prepared by using distilled water i.e. 200 mg/kg p.o. Methanolic extracts of QI significantly reduce the harmful lipid layer in blood serum at varying concentration and dose dependent manner which shows that the plant carries the hypolipidemic properties. It reduces the LDL, VLDL, cholesterol, triglyceride and raise HDL level in blood serum upto certain extent which was may be due to the inhibition of lipid peroxidation as the plants contain some active ingredients acting as antioxidants. Our result shows that the plants extracts recover the disorders in lipid metabolism noted in hyperlipidemic state.Keywords
Hypolipidemic, Hypocholesterolemic, Passive smoking (PS), Hyperlipidemia, Quisqualis indica, Coronary heart disease
References
- Barnoya, J. and S.A. Glantz, 2005. Cardiovascular effects of secondhand smoke: nearly as large as smoking Circulation 111, 2684-2698.
- California Environmental Protection Agency: Air Resources Board, 2005. Proposed identification of environmental tobacco smoke as a toxic air contaminant. Tobacco Control: Surveys and Program Evaluations from Outside UCSF, June 24, 2005. http://escholarship.org/uc/tc_surveys.
- Celermajer, D.S., K.E. Sorensen, D. Georgakopoulos, C. Bull, O. Thomas, J. Robinson and J.E. Deanfield, 1993. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation, 88: 2149-2155.
- Crowther MA., Pathogenesis of atherosclerosis, The American Society of Hematology, 2005, 1, 436.
- Davies, K.J.A., 1991. Oxidative Damage and Repair: Chemical, Biological and Medical Aspects. Pergamon Press, Oxford, UK., ISBN-13: 9780080417493, Pages: 899.
- Devi, R. and D.K. Sharma, 2004. Hypolipidemic effect of different extracts of Clerodendron colebrookianum Walp in normal and high-fat diet fed rats. J. Ethnopharmacol., 90: 63-68.
- Glantz, S.A. and W.W. Parmley, 1991, Passive smoking and heart disease: epidemiology, physiology and biochemistry. Circulation, 83, 1-12.
- Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Executive Summary. Available at: http://www.nhlbi.nih.gov/guidelines/ cholesterol/atp3xsum.pdf Accessed April 16, 2001.
- Third Report of the National Cholesterol Education Program (NCEP) Expert Panel, On Detection, Evaluation and Treatment of High Blood Cholesterol in Adults, (Adult Treatment Panel III) Final Report. Circulation 2002, 106, page 3240.
- Jacobson MS. Heart healthy diets for all children: no longer controversial. J Pediatr 1998;133(1):1-2.
- Jahan, F.N., M.S. Rahman, M.M. Rahman, S. Gibbons and M.M. Masud et al., 2009. Diphenylpropanoids from Quisqualis indica Linn. and their Anti-staphylococcal Activity, Latin American Journal of Pharmacy, 28 (2): 279-83.
- Kaisar, M.A., M.R. Islam, M.S. Rahman, M.K. Hossain and M.A. Rashid, 2009. Total Phenolic Content, Free Radical Scavenging Activity and Reducing Power of Quisqualis indica Linn, Dhaka Univ. J. Pharm. Sci. 8(2), 173-175.
- Kaplan, A. and L.L. Szabo, 1983. Lipid Metabolism. In: Clinical Chemistry: Interpretation and Techniques, Kaplan, A. and L.L. Szabo (Eds.). 2nd Edn. Lea and Febiger, Philadelphia, PA., USA., ISBN-13: 9780812108736, pp: 333-336.
- Kushi, L.H., A.R. Folsom, R.J. Prineas, P.J. Mink, Y. Wu and R. Bostick, 1996. Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. N Engl J Med., 334, 1156-1162.
- Langseth, L., 1996, Oxidants, antioxidants and disease prevention, International Life Science Institute, Belgium.
- Meyer, E.L., E. Waldenlind and C. Marcus, 2005. Lipolysis in smokers during tobacco withdrawal: A pilot study. Scand. J. Clin. Lab. Invest., 65: 649-657.
- Mjos, O.D., 1988. Lipid effects of smoking. Am. Heart J., 115: 272-275.
- Singh, N., P. Khatri, K.C. Samantha and R. Damor, 2010. Antipyretic activity of methanolic extract of leaves of Quisqualis indica Linn. Int. J. Pharm. Res. Dev., 2: 122-126.
- Otsuka, R., H. Watanabe, K. Hirata, K. Tokai and T. Muro et al., 2001. Acute effects of passive smoking on the coronary circulation in healthy young adults. J. Am. Med. Assoc., 286: 436-441.
- Patil, U.K., S. Saraf and V.K. Dixit, 2004. Hypolipidemic activity of seeds of Cassia tora Linn. Journal of Ethnopharmacology 90, 249-252.
- Penn, A., L.C. Chen and C.A. Snyder, 1994. Inhalation of steadystate sidestream smoke from one cigarette promotes arteriosclerotic plaque development. Circulation, 90: 1363-1367.
- Rimm, E.B., M.J. Stampfer, A. Ascherio, E. Giovannucci, G.A. Colditz and W.C. Willett, 1993, Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med, 328, 1450- 1456.
- Shukla, R., S. Gupta, J.K. Gambhir, K.M. Paha and P.S. Murthy, 2004. Antioxidant effect of aqueous extract of the bark of Ficus bengalensis in hypercholesterolaemic rabbits. Journal of Ethnopharmacology 92, 47-51.
- Takeatsu Kimura, Northeast Asia, Volume 1, 1996, 102, Available at: http://books.google.co.in/ books?isbn=981022589X.
- Taylor, A.E., D.C. Johnson and H. Kazemi, 1992. Environmental tobacco smoke and cardiovascular disease. A position paper from the council on cardiopulmonary and critical care, American heart association. Circulation, 86: 699-702.
- Vadnere, G.P., A.V. Patil, S.K. Jain and S.S. Wagh, 2011. Investigation on in-vitro Antioxidant activity of whole plant of Cassia occidentalis Linn. (Caesalpiniaceae). Int. J. PharmTech. Res., 3: 1985-1991.
- Wetwitayaklung, P., C. Limmatvapirat, T. Phaechamud and S. Keokitichai, 2007. Kinetics of Acetylcholinesterase Inhibition of Quisqualis indica Linn. flower extract. Silpakorn U Sci. Technol. J., 1: 20-28.
- Wilson, P.W., R.D. Abbott and W.P. Castelli, 1988. High density lipoprotein cholesterol and mortality, The Framingham heart study. Arteriosclerosis 8, 737-740.
- Winniford, M.D., 1990. Smoking and cardiovascular function. J. Hypertension Suppl., 8: S17-S23.
- Yadav, Y., P.K. Mohanty and S.B. Kasture, 2011a. Antiinflammatory activity of hydroalcoholic extract of Quisqualis indica Linn. flower in rats. Int. J. Pharm. Life Sci., 2: 977-981.
- Yadav, Y., P.K. Mohanty and S.B. Kasture, 2011b. Evaluation of immunomodulatory activity of hydroalcoholic extract of Quisqualis indica Linn. flower in Wistar rats. Int. J. Pharm. Life Sci., 2: 687-694.
- Zhu, B.Q., Y.P. Sun, R.E. Sievers, W.M. Isenberg, S.A. Glantz and W.W. Parmley, 1993. Passive smoking increases experimental atherosclerosis in cholesterol-fed rabbits. J. Am. Coll. Cardiol., 21: 225-232.